Transcription Factor
| Accessions: | UP00603C (UniPROBE 20160601) |
| Names: | CRS2, FPP, Homeobox protein Hox-8, homeobox protein MSX-2, HOX8, MSH, MSX2_R172H, PFM, PFM1 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein MSX-2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. |
| Length: | 85 |
| Pfam Domains: | 14-70 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAEHAEFSSSLNLTETQVKIW 60 61 FQNRRAKAKRLQEAELEKLKMAAKP |
| Interface Residues: | 14, 15, 16, 17, 55, 56, 58, 59, 62, 63, 66, 67, 70 |
| 3D-footprint Homologues: | 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 5flv_I, 5zjt_E, 4j19_B, 3a01_E, 1jgg_B, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D, 1puf_B |
| Binding Motifs: | UP00603C_1 awwsydrACYAATTAdsgcmdy UP00603C_2 ydmmayrCyAATTrGtmwtyrs |
| Binding Sites: | AATTAATT ACCAATTA ACTAATTA ATAATTAG ATAATTGG ATCAATTA ATTAATTA ATTAATTG CAATTAAA CAATTAAC CAATTAAG CAATTATC CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG CTTAATTA GCAATTAA GCCAATTA GCTAATTA GTTAATTA TAATTAAA TAATTGGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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