Transcription Factor
| Accessions: | UP00507A (UniPROBE 20160601) |
| Names: | 153515_at, 99B, CG1897, Dmel\CG1897, l(3)FA30, ltt, Msh, msh-1, msh1, Msx, Muscle segmentation homeobox, Protein drop, Protein msh |
| Organisms: | Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Muscle segmentation homeobox: Msh plays a key role in the specification of proneural and promuscular cluster formation. It is required for the specification of dorsal and lateral muscle progenitor cells. |
| Length: | 131 |
| Pfam Domains: | 39-95 Homeobox domain |
| Sequence: (in bold interface residues) | 1 TRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREK 60 61 QYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIEKIKMAALGRGAPGAQWAM 120 121 AGYFHPSLMHL |
| Interface Residues: | 23, 24, 25, 26, 27, 31, 39, 40, 41, 42, 80, 81, 83, 84, 87, 88, 91, 92, 95 |
| 3D-footprint Homologues: | 1e3o_C, 1ig7_A, 6a8r_A, 3cmy_A, 1puf_A, 3d1n_M, 1mnm_C, 5zfz_A, 1fjl_B, 2h1k_B, 2lkx_A, 1zq3_P, 6m3d_C, 1nk2_P, 3lnq_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A, 1k61_B, 8g87_X |
| Binding Motifs: | UP00507A_1 tarcrsCrCyAATTAgygywyy |
| Binding Sites: | GGTAATTA ACCAATTA ACTAATTA AGCAATTA AGTAATTA ATAATTAC ATAATTAG ATAATTGG ATTAATTA CAATTAAA CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTAG GATAATTA GCAATTAA GCTAATTA GTAATTAA |
| Publications: | Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development 139:1164-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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