Transcription Factor
| Accessions: | eve (DrosophilaTF 1.1), T098483_1.02 (CISBP 1.02), P06602 (JASPAR 2024) |
| Names: | EVE_DROME, eve, T098483_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P06602 |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 376 |
| Pfam Domains: | 71-127 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MHGYRTYNMESHHAHHDASPVDQKPLVVDLLATQYGKPQTPPPSPNECLSSPDNSLNGSR 60 61 GSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQN 120 121 RRMKDKRQRIAVAWPYAAVYSDPAFAASILQAAANSVGMPYPPYAPAAAAAAAAAAAVAT 180 181 NPMMATGMPPMGMPQMPTMQMPGHSGHAGHPSPYGQYRYTPYHIPARPAPPHPAGPHMHH 240 241 PHMMGSSATGSSYSAGAAGLLGALPSATCYTGLGVGVPKTQTPPLDLQSSSSPHSSTLSL 300 301 SPVGSDHAKVFDRSPVAQSAPSVPAPAPLTTTSPLPAPGLLMPSAKRPASDMSPPPTTTV 360 361 IAEPKPKLFKPYKTEA |
| Interface Residues: | 71, 72, 73, 74, 76, 81, 84, 85, 87, 88, 112, 113, 115, 116, 119, 120, 123, 124, 127 |
| 3D-footprint Homologues: | 1puf_A, 1ig7_A, 6a8r_A, 2h1k_B, 3cmy_A, 5zfz_A, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 6m3d_C, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 5hod_A, 3a01_E, 1mnm_C, 5jlw_D, 1puf_B, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 1yo5_C, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 3l1p_A, 4qtr_D, 1du0_A, 1k61_B, 3d1n_M, 1o4x_A, 8g87_X |
| Binding Motifs: | MA0221.1 yTAATkA eve TCAwTTAAmT M1091_1.02 yTAAtkrsy |
| Binding Sites: | MA0221.1.16 MA0221.1.12 MA0221.1.17 MA0221.1.1 MA0221.1.10 MA0221.1.11 MA0221.1.13 MA0221.1.14 MA0221.1.15 MA0221.1.18 MA0221.1.19 MA0221.1.2 MA0221.1.20 MA0221.1.3 MA0221.1.4 MA0221.1.5 MA0221.1.6 MA0221.1.7 MA0221.1.8 MA0221.1.9 |
| Publications: | Hoey T., Levine M. Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature 332:858-861 (1988). [Pubmed] Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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