Transcription Factor

						

			
Accessions: FOSB_HUMAN (HOCOMOCO 10), P53539 (JASPAR 2024)

			
Names: FOSB_HUMAN, G0/G1 switch regulatory protein 3, Protein fosB, FosB proto-oncogene, AP-1 transcription factor subunit, Transcription factor AP-1 subunit FosB
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P53539
Length: 338
Pfam Domains:   153-211 bZIP transcription factor
  155-207 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTA   60
  61 ITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGS  120
 121 GGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELT  180
 181 DRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRD  240
 241 LPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSY  300
 301 TSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
Interface Residues: 161, 162, 165, 166, 168, 169, 172, 173, 176
3D-footprint Homologues: 7x5e_E, 5vpe_C, 7x5e_F, 2wt7_A, 4eot_A, 1skn_P, 6mg1_B, 1nwq_C, 5vpe_D, 5t01_B
Binding Motifs: UN0122.1 grTGACGTCAyc
FOSB_HUMAN.H10MO.C|M01138 grTGACTCAyc
MA1127.1 gaTGACGTCAy
MA1135.1 krTGAsTCAy
MA1136.1 rTGACGTCAy
MA1135.2 rTGAsTCAy
UN0122.2 rTGACGTCAy
			
Publications: Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol : (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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