Transcription Factor
| Accessions: | HOXB9 (HT-SELEX2 May2017) |
| Names: | ENSG00000170689, HOXB9 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 248 |
| Pfam Domains: | 1-170 Hox9 activation region 184-240 Homeobox domain |
| Sequence: (in bold interface residues) | 1 ISGTLSSYYVDSIISHESEDAPPAKFPSGQYASSRQPGHAEHLEFPSCSFQPKAPVFGAS 60 61 WAPLSPHASGSLPSVYHPYIQPQGVPPAESRYLRTWLEPAPRGEAAPGQGQAAVKAEPLL 120 121 GAPGELLKQGTPEYSLETSAGREAVLSNQRPGYGDNKICEGSEDKERPDQTNPSANWLHA 180 181 RSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEVARLLNLSERQVKIWFQNRRMKMKK 240 241 MNKEQGKE |
| Interface Residues: | 184, 185, 186, 187, 225, 226, 228, 229, 232, 233, 236, 237, 238, 240 |
| 3D-footprint Homologues: | 1ig7_A, 3cmy_A, 3d1n_M, 6a8r_A, 1fjl_B, 2h1k_B, 5zfz_A, 1puf_A, 1nk2_P, 1zq3_P, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 6m3d_C, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 1jgg_B, 7psx_B, 2hos_A, 5jlw_D, 3lnq_A, 4xrs_G, 3a01_E, 1b72_A, 3rkq_B, 1e3o_C, 2xsd_C, 1au7_A, 1le8_A, 7xrc_C, 1mnm_C, 8g87_X, 1du0_A, 5hod_A, 4qtr_D, 1k61_B, 1o4x_A |
| Binding Motifs: | HOXB9_2 gTCRTAAAat HOXB9_3 GymATWAAay HOXB9_methyl_1 GTCGTAAAmy |
| Related annotations: | PaperBLAST |
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