Transcription Factor

Accessions: 4rod_B (3D-footprint 20231221), 4roe_B (3D-footprint 20231221)
Names: TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP_HUMAN, Transcription initiation factor TFIID TBP subunit
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P20226
Length: 177
Pfam Domains: 6-88 Transcription factor TFIID (or TATA-binding protein, TBP)
94-176 Transcription factor TFIID (or TATA-binding protein, TBP)
Sequence:
(in bold interface residues)
1 PSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSG 60
61 KMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTH 120
121 QQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKG
Interface Residues: 10, 12, 40, 41, 55, 57, 63, 65, 99, 100, 102, 131, 132, 146, 148, 154, 156
3D-footprint Homologues: 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G, 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D, 6cnb_R, 1cdw_A
Binding Motifs: 4rod_AB GAnnCTTATATAnCTG
4roe_AB GAnnCTTATAAGnnc
Binding Sites: 4rod_N
4rod_T
4roe_N
4roe_T
Publications: Gouge J, Satia K, Guthertz N, Widya M, Thompson AJ, Cousin P, Dergai O, Hernandez N, Vannini A. Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell 163:1375-87 (2015). [Pubmed]
Related annotations: PaperBLAST

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