Transcription Factor
| Accessions: | UP00089A (UniPROBE 20160601), UP00390A (UniPROBE 20160601) |
| Names: | AI323641, hepatocyte nuclear factor 1, Hepatocyte nuclear factor 1-alpha, Hnf-1, Hnf-1a, HNF1, HNF1-alpha, HNF1[a], Hnf1a, Hnf1alpha, LFB1, Liver-specific transcription factor LF-B1, Tcf-1, Tcf1, transcription factor 1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q66JY7 |
| Description: | transcription factor 1: Mus musculus transcription factor 1 (Tcf1), mRNA. |
| Length: | 114 |
| Pfam Domains: | 17-90 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKSPSKEERETLVEECNRAECIQ 60 61 RGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGP |
| Interface Residues: | 17, 20, 80, 81, 82, 83, 86, 87, 90 |
| 3D-footprint Homologues: | 1fjl_B, 5zfz_A, 1puf_B, 4j19_B, 2h8r_B, 1ic8_B, 1le8_A, 7q3o_C, 2lkx_A, 3cmy_A |
| Binding Motifs: | UP00089A_1 mctyrgTTAACyaarmr UP00390A_1 ysktrGTTAACtaaaak UP00089A_2 tkrycygGATTAdr |
| Binding Sites: | AAGTTAAC ACTAACTA ACTAGTTA AGTTAACC AGTTAACG CCGGTTAA CGGTTAAC CTAACTAA CTAACTAG CTAGTTAA CTGGTTAA CTTAACTA GGTTAACA GTAGTTAA GTTAACCA GTTAACTA TAACTAGA TAAGTTAA TCGGTTAA TTAACTAA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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