Transcription Factor
| Accessions: | BCL6_HUMAN (HOCOMOCO 10), P41182 (JASPAR 2024) |
| Names: | B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL6_HUMAN, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 706 |
| Pfam Domains: | 22-128 BTB/POZ domain 546-568 C2H2-type zinc finger 560-584 Zinc-finger double domain 574-596 Zinc finger, C2H2 type 574-593 C2H2-type zinc finger 574-594 Zinc-finger of C2H2 type 588-612 Zinc-finger double domain 602-624 C2H2-type zinc finger 616-641 Zinc-finger double domain 630-652 Zinc finger, C2H2 type 630-652 C2H2-type zinc finger 632-651 Zinc-finger of C2H2 type 645-668 Zinc-finger double domain 658-681 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI 60 61 FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT 120 121 CRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAF 180 181 APSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPG 240 241 EYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKAS 300 301 KEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASG 360 361 SPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP 420 421 ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGS 480 481 QSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQT 540 541 HSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEK 600 601 PYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHC 660 661 EKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC |
| Interface Residues: | 529, 531, 532, 535, 556, 557, 558, 559, 560, 562, 563, 565, 566, 567, 569, 574, 584, 585, 586, 587, 588, 590, 591, 594, 595, 612, 613, 614, 615, 616, 618, 619, 623, 640, 641, 642, 643, 644, 645, 646, 647, 648, 668, 669, 670, 671, 672, 673, 674, 675, 676, 679 |
| 3D-footprint Homologues: | 6wmi_A, 7w1m_H, 5k5l_F, 1tf6_A, 5v3j_F, 2i13_A, 5yel_A, 1ubd_C, 8cuc_F, 7y3l_A, 7n5w_A, 1mey_C, 5kl3_A, 8ssq_A, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 8h9h_G, 7eyi_G, 7ysf_A, 6blw_A, 2jpa_A, 2kmk_A, 6jnm_A, 6u9q_A, 5ei9_F, 5k5i_A, 5und_A, 2gli_A, 1g2f_F, 4x9j_A, 1llm_D, 6e94_A, 2lt7_A, 7y3m_I, 1tf3_A, 7txc_E, 2drp_D, 1f2i_J, 5yj3_D, 6a57_A, 3uk3_C, 2wbs_A, 4m9v_C |
| Binding Motifs: | MA0463.2 wyGCTTTCkAGGAAyk BCL6_HUMAN.H10MO.C|M01034 aardgcwTTCywgGAa MA0463.3 GCTTTCkAGGAAy |
| Publications: | Kawamata N., Miki T., Ohashi K., Suzuki K., Fukuda T., Hirosawa S., Aoki N. Recognition DNA sequence of a novel putative transcription factor, BCL6.. Biochem. Biophys. Res. Commun. 204:366-374 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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