DNA Binding Site

Accessions: 2wbu_B (3D-footprint 20231221), 5kea_B (3D-footprint 20231221), 5keb_B (3D-footprint 20231221)
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 10
Sequence: GAGGCGTGGC
Type: Heterodimer
Binding TFs: 2wbu_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
5kea_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
5keb_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Motifs: 2wbu_A GGGGCGTGGc
5kea_A smCACGCCY
5keb_A GcCACGCCTc
Publications: Schuetz A, Nana D, Rose C, Zocher G, Milanovic M, Koenigsmann J, Blasig R, Heinemann U, Carstanjen D. The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cellular and molecular life sciences : CMLS 68:3121-31 (2011). [Pubmed]

Hashimoto H, Wang D, Steves AN, Jin P, Blumenthal RM, Zhang X, Cheng X. Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Res 44:10177-10185 (2016). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.