DNA Binding Site

						

			
Accessions: 1jh9_B (3D-footprint 20231221), 1pnr_B (3D-footprint 20231221), 1wet_B (3D-footprint 20231221)

			
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 17
Sequence: AACGAAAACGTTTTCGT
Type: Heterodimer
Binding TFs: 1pnr_A / 1wet_A (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
1jh9_A (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
Binding Motifs: 1pnr_A CGAanACg
1jh9_A CGAanACg
1wet_A CGAanACg
			
Publications: Huffman J.L, Lu F, Zalkin H, Brennan R.G. Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. Biochemistry 41:511-20 (2002). [Pubmed]


Schumacher M.A, Choi K.Y, Zalkin H, Brennan R.G. Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (New York, N.Y.) 266:763-70 (1994). [Pubmed]


Schumacher M.A, Glasfeld A, Zalkin H, Brennan R.G. The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. The Journal of biological chemistry 272:22648-53 (1997). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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