DNA Binding Site
| Accessions: | 6wc2_F (3D-footprint 20231221), 6wc2_H (3D-footprint 20231221), 6wc2_L (3D-footprint 20231221), 6wc5_F (3D-footprint 20231221) |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Length: | 21 |
| Sequence: | CACTATTTTAAGAAAGTGCTT |
| Type: | Heterodimer |
| Binding TFs: | 6wc2_N (Homeobox domain) 6wc2_D (SRF-type transcription factor (DNA-binding and dimerisation domain)) 6wc2_M (Homeobox domain) 6wc2_O (Homeobox domain) 6wc5_I (Homeobox domain) |
| Binding Motifs: | 6wc2_ABO CTAnnnnnGGAAAAngC 6wc2_CDM GCTAnnnnnaGAAAAngC 6wc2_D caCTA 6wc2_IJN CTAnnnnnnGAAAAnGC 6wc5_ABI CnCTttCTnnnnnnAG |
| Publications: | Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed] |
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