DNA Binding Site

Accessions: GGCAAACA (UniPROBE 20160601), MA0047.4.3 (JASPAR 2024)
Organisms: Emericella nidulans, Homo sapiens
Libraries: UniPROBE 20160601 1, JASPAR 2024 2
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 8
Sequence: GGCAAACA
Type: Heterodimer
Binding TFs: Q9Y261 (Fork head domain, Forkhead N-terminal region, HNF3 C-terminal domain)
UP00518A (Fork head domain)
UP00523A (Fork head domain)
Q9Y261
Binding Motifs: UP00518A_1 cmcmhwrtrrCAAACAwhykhay
UP00518A_2 grsmyawGTTTTACAcgwkmgw
UP00523A_1 scctcdmrCAAACAahyawkrk
UP00523A_2 cmymvykArGACGCCAavwgasg
MA0047.4 wGTAAACA
Publications: Nakagawa S, Gisselbrecht SS, Rogers JM, Hartl DL, Bulyk ML. DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A 110:12349-54 (2013). [Pubmed]

Li J, Dantas Machado AC, Guo M, Sagendorf JM, Zhou Z, Jiang L, Chen X, Wu D, Qu L, Chen Z, Chen L, Rohs R, Chen Y. Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site. Biochemistry 56:3745-3753 (2017). [Pubmed]

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