DNA Binding Site

Accessions: 4hn5_C (3D-footprint 20231221), 4hn6_C (3D-footprint 20231221), 5cc0_C (3D-footprint 20231221)
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 16
Type: Heterodimer
Binding TFs: 4hn5_B (Zinc finger, C4 type (two domains))
4hn6_B (Zinc finger, C4 type (two domains))
5cc0_B (Zinc finger, C4 type (two domains))
Binding Motifs: 4hn5_AB CCnGnnGC
4hn6_AB CTcTnCcnnnnGCG
5cc0_AB CGnnnnnnGnnbd
Publications: Hudson W.H, Youn C, Ortlund E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology 20:53-8 (2013). [Pubmed]

Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.