DNA Binding Site

Accessions: GCACCTGC (UniPROBE 20160601), MA0745.3.13 (JASPAR 2024), MA0745.3.7 (JASPAR 2024), MA0745.3.8 (JASPAR 2024), MA0830.3.11 (JASPAR 2024), MA0830.3.12 (JASPAR 2024), MA0830.3.13 (JASPAR 2024), MA0830.3.19 (JASPAR 2024), UN0808.1.19 (JASPAR 2024), UN0808.1.4 (JASPAR 2024)
Organisms: Mus musculus, Caenorhabditis elegans, Homo sapiens
Libraries: UniPROBE 20160601 1, JASPAR 2024 2
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 8
Sequence: GCACCTGC
Type: Heterodimer
Binding TFs: P17542 (Helix-loop-helix DNA-binding domain)
P15884 (Helix-loop-helix DNA-binding domain)
UP00099A (Helix-loop-helix DNA-binding domain)
UP00046A (Helix-loop-helix DNA-binding domain)
UP00369A (Helix-loop-helix DNA-binding domain)
UP00379A (Helix-loop-helix DNA-binding domain)
UP00384A (Helix-loop-helix DNA-binding domain)
O43623 (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
UP00621A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
UP00621B (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
UP00621C (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
O43623
P15884
P17542
Binding Motifs: UP00046A_1 atcmvCAGGTGcraamw
UP00099A_1 ytyarCAGCTGCtvytk
UP00369A_1 mawwaawaAaadgw
UP00046A_2 arrgcCAGATGkyyssg
UP00099A_2 bymwcCCcryccyrty
UP00369A_2 / UP00384A_8 arwwyCACCTGYthawy
UP00379A_2 / UP00384A_7 mrtrmCACCTGCtaayy
UP00621A_1 wmkaratrCACCTGyTakwhmk
UP00621B_1 wwwmrakrCACCTGyTakwhaw
UP00621C_1 tadarAwrCACCTGyTakwyad
MA0745.3 gCACCTGT
MA0830.3 gCACCTGc
UN0808.1 GCACCTGg
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]

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