DNA Binding Site
| Accessions: | GCACCTGC (UniPROBE 20160601), MA0745.3.13 (JASPAR 2024), MA0745.3.7 (JASPAR 2024), MA0745.3.8 (JASPAR 2024), MA0830.3.11 (JASPAR 2024), MA0830.3.12 (JASPAR 2024), MA0830.3.13 (JASPAR 2024), MA0830.3.19 (JASPAR 2024), UN0808.1.19 (JASPAR 2024), UN0808.1.4 (JASPAR 2024) |
| Organisms: | Mus musculus, Caenorhabditis elegans, Homo sapiens |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 8 |
| Sequence: | GCACCTGC |
| Type: | Heterodimer |
| Binding TFs: | P17542 (Helix-loop-helix DNA-binding domain) P15884 (Helix-loop-helix DNA-binding domain) UP00099A (Helix-loop-helix DNA-binding domain) UP00046A (Helix-loop-helix DNA-binding domain) UP00369A (Helix-loop-helix DNA-binding domain) UP00379A (Helix-loop-helix DNA-binding domain) UP00384A (Helix-loop-helix DNA-binding domain) O43623 (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621A (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621B (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) UP00621C (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger) O43623 P15884 P17542 |
| Binding Motifs: | UP00046A_1 atcmvCAGGTGcraamw UP00099A_1 ytyarCAGCTGCtvytk UP00369A_1 mawwaawaAaadgw UP00046A_2 arrgcCAGATGkyyssg UP00099A_2 bymwcCCcryccyrty UP00369A_2 / UP00384A_8 arwwyCACCTGYthawy UP00379A_2 / UP00384A_7 mrtrmCACCTGCtaayy UP00621A_1 wmkaratrCACCTGyTakwhmk UP00621B_1 wwwmrakrCACCTGyTakwhaw UP00621C_1 tadarAwrCACCTGyTakwyad MA0745.3 gCACCTGT MA0830.3 gCACCTGc UN0808.1 GCACCTGg |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] |
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