DNA Binding Motif

						

			
Accessions: NR2F1_8 (HT-SELEX2 May2017), MA1538.1 (JASPAR 2024)

			
Names: NR2F1, NR2F1(var.3)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 15
Consensus: rrGGTCRtTGACCYy
Weblogo: 
PSSM: P0      A      C      G      T
01   1651    280   1271    312      r
02   2466     75   1049     79      r
03     44    121   3515    356      G
04     75     45   3515     67      G
05     22     87    232   3515      T
06     20   3515     58    171      C
07   2473     58   1041      4      R
08    813    855    858    990      t
09      0     89     52   3515      T
10     81     15   3515     12      G
11   3515     95      0      0      A
12      0   3515      1     45      C
13    131   3515     75     50      C
14     57    949     32   2566      Y
15    308   1177    205   1825      y
Type: Heterodimer
Binding TFs: P10589 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
NR2F1 (Zinc finger, C4 type (two domains))
P10589
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14:554-67 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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