DNA Binding Motif

						

			
Accessions: MSGN1_2 (HT-SELEX2 May2017), MA1524.1 (JASPAR 2024)

			
Names: MSGN1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 12
Consensus: srCCAwwTGkys
Weblogo: 
PSSM: P0      A      C      G      T
01   1190   2080   1615   1488      s
02   3096    576   3277    408      r
03    663   6373   1613    726      C
04      0   6373     17      0      C
05   6373      0    374      0      A
06   2424    627    112   3950      w
07   3766    190    814   2607      w
08     10    287     17   6373      T
09      0     10   6373      0      G
10    412   1132   3104   3269      k
11    514   3269   1503   3104      y
12   1388   1976   1781   1228      s
Type: Heterodimer
Binding TFs: MSGN1 (Helix-loop-helix DNA-binding domain)
A6NI15 (Helix-loop-helix DNA-binding domain)
A6NI15
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun : (2011). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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