DNA Binding Motif

						

			
Accessions: MGA_DLX2_1 (HumanTF2 1.0), UN0572.1 (JASPAR 2024)

			
Names: MGA_DLX2, MGA::DLX2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: rGGTGhTAATTr
Weblogo: 
PSSM: P0      A      C      G      T
01   1722     44    854     98      r
02    196    126   1722     36      G
03      7      3   1722      6      G
04      6    239     53   1722      T
05      6      0   1722      2      G
06    443    482    178    619      h
07    226     27     34   1722      T
08   1722     11     23      0      A
09   1722      3      0     11      A
10     35     42    101   1722      T
11    205     88    322   1722      T
12    787     55    935     51      r
Type: Heterodimer
Binding TFs: DLX2_TF2 (Homeobox domain, Homeobox protein distal-less-like N terminal )
MGA_TF1 (T-box)
DLX2_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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