DNA Binding Motif

						

			
Accessions: 6u82_D (3D-footprint 20231221)

			
Names: Double homeobox protein 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge and loop
Length: 12
Consensus: CTAATCTanTCA
Weblogo: 
PSSM: P0      A      C      G      T
01      0     96      0      0      C
02      3      3      5     85      T
03     96      0      0      0      A
04     96      0      0      0      A
05      3      5      3     85      T
06      8     72     13      3      C
07      3      3      1     89      T
08     65      8     13     10      a
09     24     24     24     24      n
10      5      3      3     85      T
11      3     85      5      3      C
12     96      0      0      0      A
Binding TFs: 6u82_D (Homeobox domain, Homeobox KN domain)
Binding Sites: 6u82_E
			
Publications: Klingler C, Ashley J, Shi K, Stiefvater A, Kyba M, Sinnreich M, Aihara H, Kinter J. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. FASEB J 34:4573-4590 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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