DNA Binding Motif

Accessions: 6u82_D (3D-footprint 20231221)
Names: Double homeobox protein 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge and loop
Length: 12
Consensus: CTAATCTanTCA
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 3 3 5 85 T
03 96 0 0 0 A
04 96 0 0 0 A
05 3 5 3 85 T
06 8 72 13 3 C
07 3 3 1 89 T
08 65 8 13 10 a
09 24 24 24 24 n
10 5 3 3 85 T
11 3 85 5 3 C
12 96 0 0 0 A
Binding TFs: 6u82_D (Homeobox domain, Homeobox KN domain)
Binding Sites: 6u82_E
Publications: Klingler C, Ashley J, Shi K, Stiefvater A, Kyba M, Sinnreich M, Aihara H, Kinter J. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. FASEB J 34:4573-4590 (2020). [Pubmed]

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