DNA Binding Motif

						

			
Accessions: 3rkq_AB (3D-footprint 20231221)

			
Names: Homeobox protein Nkx-2.5
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: NKX2.5 Homeodomain dimer bound to ANF-242 DNA
Length: 19
Consensus: TCAAGAGnnnnnCACTTCA
Weblogo: 
PSSM: P0      A      C      G      T
01      2     12      2     80      T
02      2     81      0     13      C
03     75     12      9      0      A
04     96      0      0      0      A
05      0      0     96      0      G
06     79      2     13      2      A
07      2      1     93      0      G
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     24     24     24     24      n
13      2     93      0      1      C
14     67      7     12     10      A
15      0     96      0      0      C
16      0      0      0     96      T
17      0     13      2     81      T
18      9     87      0      0      C
19     90      2      2      2      A
Type: Heterodimer
Binding TFs: 3rkq_A (Homeobox domain)
3rkq_B (Homeobox domain)
Binding Sites: 3rkq_C
3rkq_D
			
Publications: Pradhan L, Genis C, Scone P, Weinberg E.O, Kasahara H, Nam H.J. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry 51:6312-9 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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