DNA Binding Motif

						

			
Accessions: ZNF684_2 (HT-SELEX2 May2017), MA1600.1 (JASPAR 2024)

			
Names: ZNF684
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 18
Consensus: ryACAGTCCACCCCTTkr
Weblogo: 
PSSM: P0      A      C      G      T
01    524    168    362    206      r
02     82    403    314    721      y
03   1238     24     68     19      A
04      9   1253      9     19      C
05   1184     11    110    131      A
06     60    216   1135     74      G
07      9     14     59   1259      T
08     13   1236     25     10      C
09     40   1221      2     67      C
10   1012      9     57    220      A
11      3   1226     63     61      C
12     44   1253     10      6      C
13      7   1229      7     92      C
14      0   1263      0      3      C
15    249    129     18   1107      T
16     56     59     14   1224      T
17    216    168    514    619      k
18    606    201    326    127      r
Type: Heterodimer
Binding TFs: Q5T5D7 / ZNF684 (Zinc finger, C2H2 type, KRAB box, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q5T5D7
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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