DNA Binding Motif

						

			
Accessions: FOXO1_SPDEF (HumanTF2 1.0)

			
Names: FOXO1_SPDEF
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 13
Consensus: wvccGGATGTtdw
Weblogo: 
PSSM: P0      A      C      G      T
01    187     29     39    121      w
02    138    169    129     56      v
03     37    237     70      5      c
04    114    308     77     44      c
05      8      0    308     10      G
06      4      9    308      0      G
07    308      0      0     51      A
08     39     22      0    308      T
09     86     16    308      9      G
10      0     31     11    308      T
11     79     33     77    231      t
12     82      0     98    127      d
13    112     40     82    196      w
Type: Heterodimer
Binding TFs: FOXO1_TF1 / FOXO1_TF2 (Fork head domain)
SPDEF_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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