DNA Binding Motif

						

			
Accessions: CUX1_NHLH1_2 (HumanTF2 1.0)

			
Names: CUX1_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 24
Consensus: mgCAGCTGCkcymmytyATyGATc
Weblogo: 
PSSM: P0      A      C      G      T
01    442    688    174    185      m
02    162    156    929    243      g
03      0   1489      0      3      C
04   1489     14      5     20      A
05      0    131   1489     32      G
06      5   1489     37      0      C
07     15     15     15   1489      T
08      9     13   1489      0      G
09    263   1144     18     65      C
10    128    204    524    634      k
11    294    621    326    248      c
12    196    643    159    491      y
13    406    638    138    307      m
14    585    486    217    202      m
15    347    418    330    394      y
16    283    369    284    554      t
17    253    435    291    511      y
18   1489     10     20     40      A
19     71      3     17   1489      T
20      0    963     93    526      y
21    145     33   1489      0      G
22   1489     15      7      1      A
23     86    123      0   1489      T
24    305    762    163    259      c
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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