DNA Binding Motif

						

			
Accessions: UP00614B_1 (UniPROBE 20160601)

			
Names: NBLST2, NBPhox, Neuroblastoma Phox, paired mesoderm homeobox protein 2B, Paired-like homeobox 2B, PHOX2B homeodomain protein, PHOX2B_Q143R_R1, PMX2B
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 23
Consensus: wsvgakssTAATTAgsmawwwmw
Weblogo: 
PSSM: P0      A      C      G      T
01   0.43   0.10   0.08   0.39      w
02   0.13   0.35   0.32   0.20      s
03   0.25   0.29   0.34   0.12      v
04   0.17   0.07   0.61   0.15      g
05   0.46   0.15   0.17   0.22      a
06   0.11   0.20   0.36   0.33      k
07   0.24   0.27   0.39   0.10      s
08   0.13   0.47   0.28   0.13      s
09   0.08   0.18   0.06   0.68      T
10   0.71   0.03   0.20   0.06      A
11   0.93   0.02   0.04   0.01      A
12   0.01   0.04   0.02   0.93      T
13   0.06   0.20   0.03   0.71      T
14   0.68   0.06   0.18   0.08      A
15   0.08   0.16   0.59   0.17      g
16   0.10   0.39   0.27   0.24      s
17   0.41   0.41   0.08   0.10      m
18   0.47   0.16   0.18   0.20      a
19   0.37   0.15   0.20   0.28      w
20   0.39   0.08   0.16   0.37      w
21   0.41   0.18   0.12   0.29      w
22   0.37   0.28   0.12   0.24      m
23   0.52   0.09   0.04   0.35      w
Binding TFs: UP00614B (Homeobox domain)
Binding Sites: GGTAATTA
AATTAGCG
ACCAATTA
ACTAATTA
AGTAATTA
ATAATTAG
ATAATTAT
ATAATTGG
ATTAATTA
CATAATTA
CCTAATTA
CGTAATTA
CTAATTAC
CTAATTAG
GATAATTA
GCTAATTA
GTAATTAC
TTAATTAA
CAATTATG
CCAATTAC
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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