DNA Binding Motif

						

			
Accessions: MA0002.2 (JASPAR 2024)

			
Names: RUNX1
Organisms: Homo sapiens, Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: ChIP-seq
Length: 11
Consensus: ktyTGTGGttw
Weblogo: 
PSSM: P0      A      C      G      T
01    287    496    696    521      k
02    234    485    467    814      t
03    123   1072    149    656      y
04     57      0      7   1936      T
05      0     75   1872     53      G
06     87    127     70   1716      T
07      0      0   1987     13      G
08     17     42   1848     93      G
09     10    400    251   1339      t
10    131    463     81   1325      t
11    500    158    289   1053      w
Type: Heterodimer
Binding TFs: Q01196 (Runt domain, Runx inhibition domain)
Q01196
			
Publications: Meyers S., Downing J. R., Hiebert S. W. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins:the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345 (1993). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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