DNA Binding Motif

						

			
Accessions: HES7_DBD (HumanTF 1.0), MA0822.1 (JASPAR 2024)

			
Names: HES7
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: yGGCACGTGCCr
Weblogo: 
PSSM: P0      A      C      G      T
01    168    790     43    863      y
02     24     19   1864      3      G
03    160     29   1864      2      G
04      1   1864      0      3      C
05   1864      3      7      0      A
06      0   1864      0      0      C
07      4      1   1864      1      G
08      3      3      1   1864      T
09      2      1   1864      0      G
10      8   1864      5     93      C
11      0   1864      9      9      C
12    946     47    734    137      r
Type: Heterodimer
Binding TFs: HES7_DBD (Helix-loop-helix DNA-binding domain)
Q9BYE0 (Helix-loop-helix DNA-binding domain)
Q9BYE0
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Chen J, Kang L, Zhang N. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43:196-204 (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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