DNA Binding Motif

						

			
Accessions: CLOCK_NHLH1_1 (HumanTF2 1.0)

			
Names: CLOCK_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: cgCAGsTGckmcvrCACGTGbm
Weblogo: 
PSSM: P0      A      C      G      T
01    181    461    205     60      c
02    105     96    542    165      g
03     53    908     27     59      C
04    908     82     45     35      A
05     39    121    908    165      G
06    185    908    394     81      s
07     84     66     54    908      T
08     12     14    908     37      G
09    194    436    138    140      c
10     54    175    302    377      k
11    295    330    219     64      m
12    114    461    152    181      c
13    273    266    247    122      v
14    368    199    339      1      r
15     56    908      0      0      C
16    908      0     27      5      A
17      3    908     18    147      C
18     47      5    908      7      G
19     21    109      7    908      T
20      0      1    908     15      G
21     27    266    258    356      b
22    237    475    166     30      m
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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