DNA Binding Motif

						

			
Accessions: ALX4_TBX21_1 (HumanTF2 1.0)

			
Names: ALX4_TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 25
Consensus: rgGTGykAATwawmrtysrCAsykm
Weblogo: 
PSSM: P0      A      C      G      T
01   8738     21   3689   1488      r
02   4635   1322  12428    695      g
03     14    206  12428    879      G
04     25   1503    106  12428      T
05      3      0  12428     29      G
06   1810   4089    560   5969      y
07   4278    257   5755  12428      k
08  12428      6     94     45      A
09  12428     97    831     56      A
10    247   1637    432  12428      T
11   3893   1602   1424   5510      w
12   7204    292   2997   1934      a
13   5617   1860    301   4649      w
14   4412   4210    843   2963      m
15   4113   2288   3946   2082      r
16   2296   2717   2684   4731      t
17    625   4285     46   7472      y
18   2881   4836   3798    912      s
19   6147    103   4520   1658      r
20     29  12428      3    154      C
21  12428     65   1640    147      A
22     94   7449   4979     70      s
23   1425   6704   2621   5723      y
24   2350   1991   3132   4955      k
25   5474   3851   1068   2035      m
Type: Heterodimer
Binding TFs: ALX4_TF2 (Homeobox domain)
TBX21_TF2 (T-box)
ALX4_TF1 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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