DNA Binding Motif

						

			
Accessions: UP00595D_1 (UniPROBE 20160601)

			
Names: HHO.C1, Homeobox protein HHO.C1, Homeobox protein Hox-2C, homeobox protein Hox-B7, Hox-2.3, HOX2, HOX2C, HOXB7_R189C_R1
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 22
Consensus: dkwdwwATrTATAtATartrdv
Weblogo: 
PSSM: P0      A      C      G      T
01   0.31   0.12   0.32   0.26      d
02   0.20   0.12   0.32   0.36      k
03   0.25   0.24   0.06   0.44      w
04   0.28   0.09   0.30   0.33      d
05   0.29   0.14   0.05   0.52      w
06   0.28   0.12   0.07   0.53      w
07   0.73   0.07   0.17   0.04      A
08   0.04   0.10   0.03   0.83      T
09   0.29   0.20   0.41   0.10      r
10   0.13   0.04   0.06   0.76      T
11   0.68   0.02   0.23   0.07      A
12   0.07   0.23   0.02   0.68      T
13   0.76   0.06   0.04   0.13      A
14   0.18   0.23   0.17   0.42      t
15   0.83   0.03   0.10   0.04      A
16   0.04   0.17   0.07   0.73      T
17   0.42   0.21   0.14   0.23      a
18   0.26   0.13   0.51   0.10      r
19   0.24   0.11   0.24   0.41      t
20   0.42   0.18   0.28   0.11      r
21   0.38   0.09   0.28   0.25      d
22   0.25   0.34   0.27   0.14      v
Binding TFs: UP00595D (Homeobox domain)
Binding Sites: AAATATAT
AATATATA
AATATATT
ATAATATA
ATAATTAT
ATATATTA
ATATTATG
TATTAATA
TTATATAA
AAATGTAT
AACTAATA
ACAATATA
ACATATCA
ACATATTC
ATATAACA
ATTTGTAA
GTTATATA
TACAAATA
TACTATAA
TATACATA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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