DNA Binding Motif

						

			
Accessions: 6wc5_CDN (3D-footprint 20231221)

			
Names: Myocyte-specific enhancer factor 2B
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Length: 14
Consensus: CTTTCynnnnnTAG
Weblogo: 
PSSM: P0      A      C      G      T
01      6     76     12      2      C
02      0      0      0     96      T
03      0      0      7     89      T
04      0      6      0     90      T
05      0     96      0      0      C
06     12     51      6     27      y
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12     12      8      6     70      T
13     90      0      6      0      A
14      0      0     96      0      G
Type: Heterodimer
Binding TFs: 6wc5_C / 6wc5_D (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc5_N (Homeobox domain)
Binding Sites: 6wc5_G
6wc5_H
			
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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