DNA Binding Motif

						

			
Accessions: GCM1_TBX21_1 (HumanTF2 1.0), UN0550.1 (JASPAR 2024)

			
Names: GCM1_TBX21, GCM1::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: aGGTGtsrTGcGGGyk
Weblogo: 
PSSM: P0      A      C      G      T
01   1588    210    448    351      a
02    232    206   1588    214      G
03      0     48   1588     72      G
04     55    494    186   1588      T
05     29      1   1588     21      G
06    278    183    311   1588      t
07    140    703    485    259      s
08    916     83    671     12      r
09    122     26    211   1588      T
10    189     20   1399      2      G
11    117   1588    343    289      c
12     51      0   1588     16      G
13      2      3   1588     17      G
14     26      0   1588      0      G
15    171    488    312    617      y
16    195    271    549    573      k
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
TBX21_TF2 (T-box)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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