DNA Binding Motif

						

			
Accessions: GCM1_ELK3_2 (HumanTF2 1.0), UN0543.1 (JASPAR 2024)

			
Names: GCM1_ELK3, GCM1::ELK3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: rTGCGGGCGGAAGtg
Weblogo: 
PSSM: P0      A      C      G      T
01   1376    104    653     28      r
02     40     72    128   2060      T
03    411     61   2056     15      G
04    172   1953    339    294      C
05     25      5   2091     15      G
06      1     49   2123      0      G
07      0      0   2127      0      G
08     82   2118     56     57      C
09      8     21   2120     27      G
10     72      9   2111     66      G
11   2119     87    162    109      A
12   2026     97    198    227      A
13    227     46   2040     22      G
14    154    423    399   1893      t
15    481    109   1177    355      g
Type: Heterodimer
Binding TFs: ELK3_TF2 (Ets-domain)
GCM1_TF1 (GCM motif protein)
Q9NP62 (GCM motif protein)
Q9NP62
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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