DNA Binding Motif

						

			
Accessions: HES1_2 (HT-SELEX2 May2017), MA1099.2 (JASPAR 2024)

			
Names: HES1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: ggCrCGTGbc
Weblogo: 
PSSM: P0      A      C      G      T
01   3321   3492  18526   4239      g
02   5858   2072  18526   8007      g
03    464  18526      0     18      C
04   9446      0   9081    232      r
05      0  18526      0    791      C
06     21      0  18526      0      G
07    253   4057      0  18526      T
08      1      0  18526     53      G
09   1126   6203   6360   4837      b
10   2742  12513   6013   3216      c
Type: Heterodimer
Binding TFs: Q14469 (Helix-loop-helix DNA-binding domain, Hairy Orange)
HES1 (Helix-loop-helix DNA-binding domain)
Q14469
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Murata K, Hattori M, Hirai N, Shinozuka Y, Hirata H, Kageyama R, Sakai T, Minato N. Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol 25:4262-71 (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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