DNA Binding Motif

						

			
Accessions: GCM1_ETV4 (HumanTF2 1.0), UN0544.1 (JASPAR 2024)

			
Names: GCM1_ETV4, GCM1::ETV4
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 15
Consensus: aTrCGGGCGGAAGyr
Weblogo: 
PSSM: P0      A      C      G      T
01   1330    323    389    140      a
02    351    265     23   2103      T
03    827    154    968      0      r
04    294   2348    211    342      C
05     45     50   1049     28      G
06     13      6   1039      0      G
07     23      4   1050      0      G
08     67   2601      0    101      C
09      8     38   1053     27      G
10     68     13   1055     39      G
11   2274      0      9     87      A
12   2214    153      0    413      A
13    360     84   1010     31      G
14    197    871    215   1759      y
15    580    183    720    231      r
Type: Heterodimer
Binding TFs: ETV4_TF2 (Ets-domain)
GCM1_TF1 (GCM motif protein)
Q9NP62 (GCM motif protein)
Q9NP62
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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