DNA Binding Motif

						

			
Accessions: 1j47_A (3D-footprint 20231221)

			
Names: SEX-DETERMINING REGION Y PROTEIN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: 3D Solution NMR Structure of the M9I Mutant of the HMG-Box Domain of the Human Male Sex Determining Factor SRY Complexed to DNA
Length: 6
Consensus: ACAAAC
Weblogo: 
PSSM: P0      A      C      G      T
01     76      6      6      8      A
02      6     78      6      6      C
03     76      6      6      8      A
04     78      6      6      6      A
05     89      7      0      0      A
06      6     90      0      0      C
Binding TFs: 1j47_A (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 1j47_B
1j47_C
			
Publications: Murphy E.C, Zhurkin V.B, Louis J.M, Cornilescu G, Clore G.M. Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation. Journal of molecular biology 312:481-99 (2001). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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