DNA Binding Motif

Accessions: 2er8_AB (3D-footprint 20231221)
Names: Regulatory protein LEU3
Organisms: Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of Leu3 DNA-binding domain complexed with a 12mer DNA duplex
Length: 9
Consensus: cCGGnnCCg
Weblogo:
PSSM: P0 A C G T
01 16 45 19 16 c
02 9 67 11 9 C
03 6 6 78 6 G
04 4 4 84 4 G
05 24 24 24 24 n
06 24 24 24 24 n
07 2 88 2 4 C
08 4 81 4 7 C
09 10 10 63 13 g
Type: Heterodimer
Binding TFs: 2er8_A (Fungal Zn(2)-Cys(6) binuclear cluster domain)
2er8_B (Fungal Zn(2)-Cys(6) binuclear cluster domain)
Binding Sites: 2er8_E / 2er8_F
Publications: Fitzgerald M.X, Rojas J.R, Kim J.M, Kohlhaw G.B, Marmorstein R. Structure of a Leu3-DNA complex: recognition of everted CGG half-sites by a Zn2Cys6 binuclear cluster protein. Structure (London, England : 1993) 14:725-35 (2006). [Pubmed]

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