DNA Binding Motif

						

			
Accessions: 6od3_ABH (3D-footprint 20231221)

			
Names: Transcription factor 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence
Length: 6
Consensus: CACGTG
Weblogo: 
PSSM: P0      A      C      G      T
01      9     67     11      9      C
02     96      0      0      0      A
03      0     96      0      0      C
04      0      0     96      0      G
05     11      9      9     67      T
06      9      9     67     11      G
Type: Heterodimer
Binding TFs: 6od3_A (Helix-loop-helix DNA-binding domain)
6od3_B (Helix-loop-helix DNA-binding domain)
6od3_H (Helix-loop-helix DNA-binding domain)
Binding Sites: 6od3_W / 6od3_X
			
Publications: Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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