DNA Binding Motif

						

			
Accessions: 6od5_CD (3D-footprint 20231221)

			
Names: Transcription factor 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines
Length: 6
Consensus: CACGTG
Weblogo: 
PSSM: P0      A      C      G      T
01      0     96      0      0      C
02     96      0      0      0      A
03      4     81      7      4      C
04      1      2     92      1      G
05      1      1      1     93      T
06      0      0     96      0      G
Type: Heterodimer
Binding TFs: 6od5_D (Helix-loop-helix DNA-binding domain)
6od5_C (Helix-loop-helix DNA-binding domain)
Binding Sites: 6od5_E
6od5_F
			
Publications: Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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