DNA Binding Motif

						

			
Accessions: ATF4_DBD (HumanTF 1.0), MA0833.1 (JASPAR 2024)

			
Names: ATF4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 13
Consensus: ggaTGAyGCAAYm
Weblogo: 
PSSM: P0      A      C      G      T
01    210     71    442    170      g
02    169    117    409    213      g
03    639    202    127      3      a
04      0      0      7    981      T
05     19      0   1090     11      G
06    888      0      0     25      A
07      2    372      9    470      y
08      1      0   1104      4      G
09     40    838     16    113      C
10    897     21      0      3      A
11    888      3      1      4      A
12      0    266     62    714      Y
13    414    272    101     78      m
Type: Heterodimer
Binding TFs: ATF4_DBD (bZIP transcription factor, Basic region leucine zipper)
P18848 (bZIP transcription factor, Basic region leucine zipper)
P18848
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Hai T., Liu F., Coukos W. J., Green M. R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3:2083-2090 (1989). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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