DNA Binding Motif

						

			
Accessions: THRB_3 (HT-SELEX2 May2017), MA1574.1 (JASPAR 2024)

			
Names: THRB
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 15
Consensus: rrGGTCAAAGGTCRb
Weblogo: 
PSSM: P0      A      C      G      T
01   2306   1397   3705   1219      r
02   4047    234   4579     74      r
03    167     52   8626    392      G
04    104     14   8626   1892      G
05     20    132    726   8626      T
06     35   8626    824   1851      C
07   8626     16    817     13      A
08   8626    165   2025   1587      A
09   8626     43   1900     11      A
10     24      6   8626     61      G
11     36     14   8626   2010      G
12     23    246   1400   8626      T
13    136   8626    726   2555      C
14   8626    148   3668    225      R
15   1936   2190   2160   2340      b
Type: Heterodimer
Binding TFs: P10828 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
THRB (Zinc finger, C4 type (two domains))
P10828
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Lu C, Cheng SY. Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors. J Mol Endocrinol 44:143-54 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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