DNA Binding Motif

						

			
Accessions: BHLHE23_DBD (HumanTF 1.0), MA0818.1 (JASPAR 2024)

			
Names: BHLHE23, BHLHE22
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: AmCATATGyy
Weblogo: 
PSSM: P0      A      C      G      T
01    520     26    172     21      A
02    189    229     99      4      m
03      6    520      0      0      C
04    520      6     24      8      A
05      0      2      0    520      T
06    520      4      2      2      A
07     11     48      0    520      T
08      0      2    520      4      G
09      4    193    123    201      y
10     36    254     21    520      y
Type: Heterodimer
Binding TFs: BHLHE23_DBD (Helix-loop-helix DNA-binding domain)
Q8NFJ8 (Helix-loop-helix DNA-binding domain)
Q8NFJ8
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Atchley WR, Fitch WM. A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci U S A 94:5172-6 (1997). [Pubmed]


Ross SE, McCord AE, Jung C, Atan D, Mok SI, Hemberg M, Kim TK, Salogiannis J, Hu L, Cohen S, Lin Y, Harrar D, McInnes RR, Greenberg ME. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron 73:292-303 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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