DNA Binding Motif

						

			
Accessions: TGIF2LX_4 (HT-SELEX2 May2017), MA1571.1 (JASPAR 2024)

			
Names: TGIF2LX
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 12
Consensus: TGACAgcTGTCA
Weblogo: 
PSSM: P0      A      C      G      T
01    237    355    145   2539      T
02     52    187   2539     47      G
03   2539     64    132    428      A
04     32   2539     29     59      C
05   2539     18    316     40      A
06     37    575   1566    362      g
07    380   1568    554     38      c
08     37    318     23   2539      T
09     64     23   2539     22      G
10    428    127     72   2539      T
11     45   2539    172     66      C
12   2539    132    361    232      A
Type: Heterodimer
Binding TFs: TGIF2LX (Homeobox domain, Homeobox KN domain)
Q8IUE1 (Homeobox domain, Homeobox KN domain)
Q8IUE1
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Bertolino E., Reimund B., Wildt-Perinic D., Clerc R. G. A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J. Biol. Chem. 270:31178-31188 (1995). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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