DNA Binding Motif

						

			
Accessions: SOX12_2 (HT-SELEX2 May2017), MA1561.1 (JASPAR 2024)

			
Names: SOX12
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 11
Consensus: aCCGAACAATg
Weblogo: 
PSSM: P0      A      C      G      T
01    854    267    109    138      a
02    153    854     58     78      C
03     48    854     34     56      C
04     47     26    854     48      G
05    854     26      2      1      A
06    854      2      4      0      A
07      0    854      0      3      C
08    854      0      0      0      A
09    854     91     44     20      A
10    129    211     57    854      T
11    198    210    305    141      g
Type: Heterodimer
Binding TFs: SOX12 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
O15370 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
O15370
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res 36:3101-17 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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