DNA Binding Motif

						

			
Accessions: HES6_1 (HT-SELEX2 May2017), MA1493.1 (JASPAR 2024)

			
Names: HES6
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: GGCACGTGTy
Weblogo: 
PSSM: P0      A      C      G      T
01     12     39    439     43      G
02     16     35    439     13      G
03     17    439     19     15      C
04    439      0      9     11      A
05      2    439      9     16      C
06     10     12    439      0      G
07      0      7     29    439      T
08      0      0    439      0      G
09     33     21      0    439      T
10     79    152      0    209      y
Type: Heterodimer
Binding TFs: HES6 / Q96HZ4 (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q96HZ4
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Cossins J, Vernon AE, Zhang Y, Philpott A, Jones PH. Hes6 regulates myogenic differentiation. Development 129:2195-207 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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