DNA Binding Motif

Accessions: UP00000A_2 (UniPROBE 20160601)
Names: AU022421, MAD homolog 3 (Drosophila), Madh3, mMad3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, Smad 3, Smad3
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 17
Consensus: kmmgcCCCGCCacyyyb
Weblogo:
PSSM: P0 A C G T
01 0.15 0.13 0.25 0.47 k
02 0.32 0.29 0.15 0.25 m
03 0.26 0.41 0.11 0.22 m
04 0.21 0.22 0.35 0.22 g
05 0.17 0.51 0.08 0.24 c
06 0.05 0.76 0.09 0.10 C
07 0.05 0.79 0.12 0.04 C
08 0 0.94 0.03 0.02 C
09 0.04 0.05 0.89 0.02 G
10 0 0.91 0.02 0.06 C
11 0.03 0.94 0.01 0.02 C
12 0.64 0.14 0.11 0.11 a
13 0.24 0.39 0.18 0.19 c
14 0.21 0.27 0.09 0.43 y
15 0.09 0.45 0.21 0.25 y
16 0.18 0.27 0.15 0.40 y
17 0.10 0.25 0.37 0.28 b
Binding TFs: UP00000A (MH1 domain)
Binding Sites: AACCAGAC
AATGTCTG
ACCAGACA
ACCAGACG
ACGTCTAG
ACGTCTGG
ATCCAGAC
ATGTCTAG
ATGTCTGA
ATGTCTGG
CAGACATA
CCAGACAA
CCAGACAG
CCCAGACA
CGTCTGGA
GCCAGACA
GTCTAGAC
GTCTGGAA
TCCAGACA
TCTAGACA
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

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