DNA Binding Motif

Accessions: UP00137A_1 (UniPROBE 20160601)
Names: homeo box B3, Homeobox protein Hox-B3, Hox-2.7, Hoxb-3, Hoxb3, MH-23
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 17
Consensus: wravcTMATKAgykrrw
Weblogo:
PSSM: P0 A C G T
01 0.38 0.05 0.05 0.52 w
02 0.29 0.13 0.52 0.06 r
03 0.55 0.20 0.13 0.12 a
04 0.26 0.27 0.32 0.15 v
05 0.08 0.57 0.20 0.15 c
06 0.01 0.11 0 0.88 T
07 0.74 0.26 0 0 M
08 0.98 0 0 0.01 A
09 0.01 0 0 0.98 T
10 0 0 0.26 0.74 K
11 0.88 0 0.11 0.01 A
12 0.15 0.20 0.57 0.08 g
13 0.05 0.34 0.12 0.49 y
14 0.19 0.15 0.30 0.36 k
15 0.32 0.23 0.38 0.06 r
16 0.31 0.12 0.40 0.18 r
17 0.41 0.14 0.20 0.26 w
Binding TFs: UP00137A (Homeobox domain)
Binding Sites: GGTAATTA
ACTAATGA
ACTAATTA
AGTAATTA
ATAATTAA
ATTAATGA
ATTAATTA
CCTAATTA
CTAATTAA
CTAATTAC
CTCATTAA
CTTAATTA
GATAATTA
GCTAATTA
GTAATTAA
GTAATTAC
GTCATTAA
GTTAATTA
TAATTACA
TTAATTAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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