DNA Binding Motif

						

			
Accessions: 1osl_AB (3D-footprint 20231221)

			
Names: Lactose operon repressor
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence
Length: 14
Consensus: ATnAGATATCTTAT
Weblogo: 
PSSM: P0      A      C      G      T
01     84      6      3      3      A
02      6      3      3     84      T
03     24     24     24     24      n
04     96      0      0      0      A
05      0      3     92      1      G
06     84      6      3      3      A
07      3      3      3     87      T
08     84      3      6      3      A
09      3      3      3     87      T
10      3     84      3      6      C
11      0      3      1     92      T
12      1      0      3     92      T
13     96      0      0      0      A
14      0      0      0     96      T
Binding TFs: 1osl_A / 1osl_B (Bacterial regulatory proteins, lacI family)
Binding Sites: 1osl_C / 1osl_D
			
Publications: Kalodimos C.G, Biris N, Bonvin A.M, Levandoski M.M, Guennuegues M, Boelens R, Kaptein R. Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes. Science (New York, N.Y.) 305:386-9 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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