DNA Binding Motif

						

			
Accessions: HES2_2 (HT-SELEX2 May2017), MA0616.2 (JASPAR 2024)

			
Names: HES2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: GgCACGTGyc
Weblogo: 
PSSM: P0      A      C      G      T
01    775   1193   8483    798      G
02   1501   1107   8483   1581      g
03    118   8483     85     73      C
04   6455      0   2028      0      A
05      0   8483      0    129      C
06      0      0   8483      0      G
07      0   1098      0   8483      T
08     53     15   8483      0      G
09    512   4634   1289   3849      y
10    966   4464   1735   1319      c
Type: Heterodimer
Binding TFs: HES2 (Helix-loop-helix DNA-binding domain)
Q9Y543 (Helix-loop-helix DNA-binding domain, Hairy Orange)
Q9Y543
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Ishibashi M, Sasai Y, Nakanishi S, Kageyama R. Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. Eur J Biochem 215:645-52 (1993). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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