DNA Binding Motif

						

			
Accessions: 5und_AB (3D-footprint 20231221)

			
Names: Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of CTCF(ZnF 4-10) With 28-mer DNA
Length: 25
Consensus: CCAGCAGGGGGCGcGcCCCCTGCTG
Weblogo: 
PSSM: P0      A      C      G      T
01     12     75      3      6      C
02      0     96      0      0      C
03     96      0      0      0      A
04      3      5     85      3      G
05      0     96      0      0      C
06     96      0      0      0      A
07      0      0     96      0      G
08      0      0     96      0      G
09      0      0     96      0      G
10      0      0     96      0      G
11      0      0     96      0      G
12      0     96      0      0      C
13     10     11     72      3      G
14     11     65     10     10      c
15      0      0     96      0      G
16     11     65     10     10      c
17      0     96      0      0      C
18      3     92      0      1      C
19      0     96      0      0      C
20      0     96      0      0      C
21      0      0      0     96      T
22      0      0     96      0      G
23      0     82      4     10      C
24      0      0      0     96      T
25      0      0     96      0      G
Type: Heterodimer
Binding TFs: 5und_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc-finger domain)
5und_B (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc-finger domain)
Binding Sites: 5und_C
5und_D
5und_E
5und_F
			
Publications: Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell 66:711-720 (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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