DNA Binding Motif

						

			
Accessions: HOXB2_NHLH1_2 (HumanTF2 1.0)

			
Names: HOXB2_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 21
Consensus: ryvaTywrsgyCgCAGCTGCk
Weblogo: 
PSSM: P0      A      C      G      T
01     76     31     67     32      r
02     75     94     48    113      y
03     95    112     89      0      v
04    207     55     63     54      a
05     12      0      7    207      T
06      4    137     50    207      y
07    207      0     45     84      w
08     67     23     71     45      r
09     39     66     92     11      s
10     49     14     97     47      g
11     49     89      8     60      y
12     45    157     19      0      C
13     34     29    117     27      g
14     10    207      1      0      C
15    207      0      0      4      A
16     18     61    207      0      G
17      0    207      9      0      C
18      0      9      0    207      T
19      6      9    207      0      G
20     28    140     14     24      C
21      1     27    100     78      k
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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