DNA Binding Motif

						

			
Accessions: 2ypa_AB (3D-footprint 20231221)

			
Names: T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA
Length: 8
Consensus: cCAnnTGt
Weblogo: 
PSSM: P0      A      C      G      T
01     12     60     12     12      c
02      0     96      0      0      C
03     84      0      0     12      A
04     24     24     24     24      n
05     24     24     24     24      n
06      0      0      0     96      T
07      0      0     96      0      G
08     12     12     12     60      t
Type: Heterodimer
Binding TFs: 2ypa_A (Helix-loop-helix DNA-binding domain)
2ypa_B (Helix-loop-helix DNA-binding domain)
Binding Sites: 2ypa_E
2ypa_F
			
Publications: El Omari K, Hoosdally S.J, Tuladhar K, Karia D, Hall-Ponselé E, Platonova O, Vyas P, Patient R, Porcher C, Mancini E.J. Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets. Cell reports 4:135-47 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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